Patching up a degraded endothelial glycocalyx in sepsis

Editorial FocusVascular Biology and MicrocirculationPatching up a degraded endothelial glycocalyx in sepsisXiangyu Zheng and Daniel R. MachinXiangyu ZhengDepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, Florida, United States and Daniel R. MachinDepartment of Nutrition and Integrative Physiology, Florida State University, Tallahassee, Florida, United StatesPublished Online:25 Aug 2023https://doi.org/10.1152/ajpheart.00499.2023This is the final version - click for previous versionMoreSectionsFull TextPDF (225 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat "Patching up a degraded endothelial glycocalyx in sepsis." American Journal of Physiology-Heart and Circulatory Physiology, 325(4), pp. H673–H674REFERENCES1. van den Berg BM, Nieuwdorp M, Stroes ESG, Vink H. Glycocalyx and endothelial (dys) function: from mice to men. Pharmacol Rep 58: 75–80, 2006. PubMed | Google Scholar2. Reitsma S, Slaaf DW, Vink H, van Zandvoort MAMJ, oude Egbrink MGA. The endothelial glycocalyx: composition, functions, and visualization. Pflugers Arch 454: 345–359, 2007. doi:10.1007/s00424-007-0212-8. Crossref | PubMed | ISI | Google Scholar3. Rovas A, Sackarnd J, Rossaint J, Kampmeier S, Pavenstädt H, Vink H, Kümpers P. Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study. Crit Care 25: 112, 2021. doi:10.1186/s13054-021-03520-w. Crossref | PubMed | ISI | Google Scholar4. Banerjee S, Mwangi JG, Stanley TK, Mitra R, Ebong EE. Regeneration and assessment of the endothelial glycocalyx to address cardiovascular disease. Ind Eng Chem Res 60: 17328–17347, 2021. doi:10.1021/acs.iecr.1c03074.Crossref | ISI | Google Scholar5. Machin DR, Sabouri M, Zheng X, Donato AJ. Therapeutic strategies targeting the endothelial glycocalyx. Curr Opin Clin Nutr Metab Care, 2023. doi:10.1097/MCO.0000000000000973.Crossref | PubMed | Google Scholar6. Machin DR, Trott DW, Gogulamudi VR, Islam MT, Bloom SI, Vink H, Lesniewski LA, Donato AJ. Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction. Geroscience, 2023. doi:10.1007/s11357-023-00745-1.Crossref | PubMed | ISI | Google Scholar7. Ishiko S, Ben Rahoma G, Kandhi S, Huang A, Sun D. Liposomal nanocarriers of preassembled glycocalyx expeditiously restore endothelial glycocalyx in endotoxemia. Am J Physiol Heart Circ Physiol 325: H645–H655, 2023. doi:10.1152/ajpheart.00196.2023. Link | Google Scholar8. Urban C, Hayes HV, Piraino G, Wolfe V, Lahni P, O'Connor M, Phares C, Zingarelli B. Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice. Front Immunol 13: 984298, 2022. doi:10.3389/fimmu.2022.984298. Crossref | PubMed | ISI | Google Scholar9. Goligorsky MS, Sun D. Glycocalyx in endotoxemia and sepsis. Am J Pathol 190: 791–798, 2020. doi:10.1016/j.ajpath.2019.06.017. Crossref | PubMed | ISI | Google Scholar10. Zheng XY, Deacon C, King AJ, Machin DR. Microcirculatory and glycocalyx properties are lowered by high-salt diet but augmented by Western diet in genetically heterogeneous mice. Am J Physiol Heart Circ Physiol 322: H328–H335, 2022. doi:10.1152/ajpheart.00656.2021. Link | ISI | Google Scholar11. Zheng X, Li Z, Berg Sen J, Samarah L, Deacon CS, Bernardo J, Machin DR. Western diet augments metabolic and arterial dysfunction in a sex-specific manner in outbred, genetically diverse mice. Front Nutr 9: 1090023, 2022. doi:10.3389/fnut.2022.1090023. Crossref | PubMed | ISI | Google Scholar Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsAJP-Heart CollectionsVascular Biology and Microcirculation Related ArticlesLiposomal nanocarriers of preassembled glycocalyx expeditiously restore endothelial glycocalyx in endotoxemia 25 Aug 2023American Journal of Physiology-Heart and Circulatory Physiology More from this issue > Volume 325Issue 4October 2023Pages H673-H674 Crossmark Copyright & PermissionsCopyright © 2023 the American Physiological Society.https://doi.org/10.1152/ajpheart.00499.2023PubMed37594482History Received 11 August 2023 Accepted 15 August 2023 Published online 25 August 2023 Published in print 1 October 2023 Keywordsendotoxemiaglycocalyxliposomemicrocirculationsyndecan-1 Metrics