Is the One-Compartment Model with First Order Absorption a Useful Approximation?

Pharmaceutical research（2023）

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摘要

The Bateman function appears to be useful for estimating the population mean value of AUC after oral administration. The results reemphasize the fact that insight into the absorption process can be only gained when also intravenous reference data are available.

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关键词

bateman function, inverse gaussian function, model misspecification, population pharmacokinetics

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