A sweet way to regulate cellular growth: OGT and mTOR join forces.

Molecular cell（2023）

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摘要

In this issue, Xu and Pan et al1 report a glucose-sensing and activation mechanism of mTORC1 through the glycosyltransferase OGT, which activates Raptor, allowing lysosomal targeting of mTORC1 to promote cell proliferation.

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