Acute effects of Δ9-tetrahydrocannabinol (THC) on resting state connectivity networks and impact of COMT genotype: A multi-site pharmacological fMRI study

Teuntje A.D. Pelgrim,Johannes G. Ramaekers,Matthew B. Wall,Tom P. Freeman,Matthijs G. Bossong

Drug and Alcohol Dependence（2023）

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摘要

•Acute THC reduced resting state functional connectivity in the salience network.•COMT genotype modulated subjective THC-induced feelings of dysphoria.•COMT modulated THC effects on connectivity in hippocampus-midbrain-striatum network.•Only Met homozygotes showed stronger dysphoria and reduced connectivity after THC.•Findings suggest involvement of prefrontal dopamine levels in acute effects of THC..

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关键词

Tetrahydrocannabinol,Resting state fMRI,Psychosis,Functional networks,Brain-imaging,Pharmacogenetics

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