Identification of HPV16 positive cervical cancer subsets characterized by divergent immune and oncogenic phenotypes with potential implications for immunotherapy.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine(2023)
摘要
Our study provides strong evidence that only a subset, about 41% of HPV16 positive CaCx patients in India, portray immune enrichment of the tumor milieu coupled with aggressive phenotypes. Such subtypes are therefore likely to benefit through checkpoint molecule-based or tumor infiltrating lymphocyte-based immunotherapy, which could be a leap forward in tackling aggressive forms of such CaCx in India and other developing countries.
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关键词
positive cervical cancer subsets,cervical cancer,hpv16,immunotherapy,oncogenic phenotypes
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