Fibrinogen BOE II: dysfibrinogenemia with bleeding and defective thrombin binding

Yang Li,Qian Liang,Wenman Wu,Xiaobo Hu, Hualiang Wang,Xuefeng Wang,Qiulan Ding

Research and practice in thrombosis and haemostasis（2023）

引用 0|浏览5

暂无评分

摘要

•Fibrinogen variants located at thrombin-binding sites may lead to hemorrhage or thrombosis.•AαGlu39 and BβAla68 of fibrinogen are crucial for fibrin(ogen)-thrombin–nonsubstrate binding.•Homozygous AαGlu39Lys variant affects thrombin-binding capacity and causes a bleeding phenotype.•Heterozygous AαGlu39Lys carrier is asymptomatic and may be missed by routine screening tests.

查看译文

关键词

dysfibrinogenemia,fibrinogen,fibrinolysis,hemorrhage,thrombin

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要