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An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation

Daniela Ricci,Stephen Tutton,Ilaria Marrocco,Mingjie Ying,Daniel Blumenthal,Daniela Eletto,Jade Vargas,Sarah Boyle,Hossein Fazelinia, Lei Qian,Krishna Suresh,Deanne Taylor,James C. Paton,Adrienne W. Paton,Chih-Hang Anthony Tang,Chih-Chi Andrew Hu,Ravi Radhakrishnan,Tali Gidalevitz,Yair Argon

Journal of Biological Chemistry（2021）

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关键词
kinase RNase interdomain helix,RNase activity,IRE1 oligomerization,differential autophosphorylation,conformational change
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