Hybrid Vesicles Enable Mechano-Responsive Hydrogel Degradation

Stimuli-responsive hydrogels are intriguing biomimetic materials. Previous efforts to develop mechano-responsive hydrogels have mostly relied on chemical modifications of the hydrogel structures. Here, we present a simple, generalizable strategy that confers mechano-responsive behavior on hydrogels. Our approach involves embedding hybrid vesicles, composed of phospholipids and amphiphilic block copolymers, within the hydrogel matrix to act as signal transducers. Under mechanical stress, these vesicles undergo deformation and rupture, releasing encapsulated compounds that can control the hydrogel network. To demonstrate this concept, we embedded vesicles containing ethylene glycol tetraacetic acid (EGTA), a calcium chelator, into a calcium-crosslinked alginate hydrogel. When compressed, the released EGTA sequesters calcium ions and degrades the hydrogel. This study provides a novel method for engineering mechano-responsive hydrogels that may be useful in various biomedical applications. We herein report a strategy that enables the development of a mechano-responsive hydrogel capable of on-demand degradation. Phospholipid-block copolymer hybrid vesicles embedded in a hydrogel matrix can act as signal transducers, releasing encapsulated compounds that control the hydrogel network when an external compressive stress is applied. This generalizable approach holds promise for the creation of diverse functional hydrogels.+image