Dihydro-β-agarofuran sesquiterpenoids from the roots of Tripterygium regelii and their inhibitory effect on NO production

Two new dihydro-β-agarofuran sesquiterpenoids (1 and 2) together with eight known analogs (3–10) were isolated from the roots of Tripterygium regelii. The chemical structures of these isolates were determined by 1D and 2D NMR, HRESIMS, and X-ray crystallography. In addition, all compounds were evaluated for their anti-inflammatory activity using the LPS-induced RAW 264.7 inflammatory cell model. Compounds 1 and 10 inhibited NO production in RAW 264.7 cells by more than 70 % at 100 μM.