A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer’s disease

Min Xiong,Li Zou,Lanxia Meng,Xingyu Zhang, Ye Tian,Guoxin Zhang,Jiaolong Yang,Guiqin Chen,Jing Xiong,Keqiang Ye,Zhentao Zhang

Progress in Neurobiology（2021）

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摘要

•AEP age-dependently cleaves γ-adducin at N357 in AD.•The AEP-generated γ-adducin (1-357) fragment translocates into nucleus and inhibits neurites growth.•γ-adducin (1-357) fragment induces neurites deficits and synaptic dysfunction by downregulating Rac2.•γ-adducin (1-357) fragment promotes AD-like pathology and cognitive impairments in vivo.

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关键词

Alzheimer’s disease,Asparagine endopeptidase,γ-adducin,Rac2,Neurite deficits

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