A pH‐Responsive Cluster Metal–Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect (Adv. Mater. 42/2022)

Ruoyu Chen,Lingxi Jiang,Han Gao,Zehua Liu,Ermei Mäkilä,Shiqi Wang,Qimanguli Saiding, Lei Xiang,Xiaomei Tang, Mingjun Shi,Jia Liu,Libin Pang,Jarno Salonen,Jouni Hirvonen,Hongbo Zhang,Wenguo Cui,Baiyong Shen,Hélder A. Santos

Advanced Materials（2022）

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摘要

Tumor Therapy A pH-responsive cluster metal–organic framework nanoparticle is developed by Wenguo Cui, Baiyong Shen, Hélder A. Santos, and co-workers in article number 2203915, based on acid-induced conversion from hydrophilicity to hydrophobicity, leading to aggregated nanoparticles. These nanoparticles inhibit tumor growth and reactivate the tumor microenvironment in both pancreatic and breast cancer models.

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关键词

metal–organic framework nanoparticle,enhanced tumor accumulation,antitumor effect

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