Effects of Terpenes on the Osteoarthritis Cytokine Profile by Modulation of IL-6: Double Face versus Dark Knight?

Giacomo Farì,Marisa Megna,Salvatore Scacco,Maurizio Ranieri,Maria Vittoria Raele,Enrica Chiaia Noya,Dario Macchiarola,Francesco Paolo Bianchi, Davide Carati,Antonio Gnoni,Alessio Danilo Inchingolo,Erda Qorri,Antonio Scarano, Antonio Scacco,Roberto Arrigoni,Biagio Rapone

Biology（2023）

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摘要

Hemp seed oil and terpene treatment modified the IL-1β and IL-6 levels, counteracting KOA inflammation in this way. In this study, IL-6 revealed its new and alternative action, since it is traditionally known as a pro-inflammatory factor, but it recently has been found to have anti-inflammatory activity in the muscle-derived form, which is the one it assumes as a myokine when activated by terpenes.

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关键词

IL-6,dietary supplement,hemp seed oil,myokines,nutraceuticals,osteoarthritis of the knee,terpenes

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