Cardiac Abnormalities in Hispanic Women with Prior De Novo Hypertensive Disorders of Pregnancy

Background. Hypertensive disorders of pregnancy (HDP) are associated with longer-term maternal risks for cardiovascular disease for reasons that remain incompletely understood. Methods. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a multi-center community-based cohort of Hispanic/Latino adults recruited 2008 to 2011 was used to evaluate the associations of history of de novo HDP (gestational hypertension, preeclampsia, eclampsia) with echocardiographic measures of left ventricular (LV) structure and function in Hispanic/Latina women with ≥1 prior pregnancy and the proportion of association mediated by current hypertension. Results. The study cohort included 5,168 Hispanic/Latina women. Prior de novo HDP was reported by 724 (14%) of the women studied with an average age of 58.7 ± 9.7 years at time of echocardiogram and was associated with lower ejection fraction -0.66 (-1.21, -0.11), greater relative wall thickness (RWT) 0.09 (0, 0.18), and 1.39 (1.02, 1.89) greater odds of abnormal LV geometry after adjusting for blood pressure and other risk factors. The proportion of association mediated by current hypertension between HDP and LV ejection fraction was 0.09 (95% CI 0.03, 0.45), any abnormal LV geometry was 0.14 (0.12, 0.48), LV RWT 0.28 (0.16, 0.51), concentric LVH was 0.31 (0.19, 0.86), and abnormal LV diastolic dysfunction was 0.58 (0.26, 1.79). Conclusions. In a large cohort of Hispanic/Latina women those with de novo HDP had detectable and measurable subclinical alterations in cardiac structure and both systolic and diastolic dysfunction that were only partially mediated by current hypertension. ### Competing Interest Statement The authors have declared no competing interest. ### Clinical Trial N/A ### Funding Statement The HCHS/SOL study is a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts N01-HC65233, N01-HC65234, N01-HC65235, N01-HC65236, and N01-HC65237. The following institutes, centers, or offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Center on Minority Health and Health Disparities, the National Institute on Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. The authors report the following additional sources of funding: NIH K23-HL136853, NIH K23-HL151867, Erika J. Glazer Women's Heart Research Initiative, and the Barbra Streisand Women's Cardiovascular Research and Education Program. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: N/A I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes Data from the HCHS/SOL cohort is publicly available to researchers upon application to NHLBI BIOLINCC.