Kynurenine pathway dynamics in patients with schizophrenia spectrum disorders across the disease trajectory

·Plasma samples from patients with schizophrenia spectrum disorder were studied at three time points over a 5-year period.·Strongest changes in the kynurenine pathway were seen in antipsychotic-naïve patients.·There was a trend of inhibited KAT-II-driven events compared to KMO-related events.·Changes in the kynurenine pathway were associated with obesity and metabolic syndrome.