Metformin Protects Against Noise-Induced Hearing Loss in Male Mice.

Catherine L Kennedy,Benjamin Shuster, Reza Amanipour,Beatrice Milon,Priya Patel,Ran Elkon,Ronna Hertzano

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology（2023）

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摘要

Metformin exhibits sex-dependent efficacy as a therapeutic for NIHL. These data compel continued investigation into metformin's protective effects and demonstrate the importance of evaluating the therapeutic efficacy of drugs in subjects of both sexes.

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关键词

Metformin, Mouse model, Noise-induced hearing loss, Otoprotection, Sex differences, Therapeutic

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