Gonadotropin-Releasing Hormone Agonist Therapy and Longitudinal Bone Mineral Density in Congenital Adrenal Hyperplasia.

Myrto Eleni Flokas,Paul Wakim,Sarah Kollender,Ninet Sinaii,Deborah P Merke

The Journal of clinical endocrinology and metabolism（2023）

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摘要

In children with CAH, GnRHa does not compromise BMD. However, BMD decreases with time and during the second and third decades of life, a possible effect of chronic supraphysiologic glucocorticoids. Children with CAH who experience early puberty benefit from GnRHa treatment as evidenced by the positive effect on height.

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congenital adrenal hyperplasia, CAH, bone density, precocious puberty, GnRH agonists

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