Microglia depletion ameliorates neuroinflammation, anxiety-like behavior, and cognitive deficits in a sex-specific manner in Rev-erbα knockout mice

Ruizhuo Chen,Brandy N. Routh,Jillian E. Straetker,Cecily R. Gibson, Aidan S. Weitzner,Kiersten S. Bell,Andrew D. Gaudet,Laura K. Fonken

Brain, Behavior, and Immunity（2023）

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摘要

•RKO potentiates neuroinflammation that is exacerbated in females.•Depleting microglia fully rescues RKO-induced neuroinflammation in males.•Depleting microglia partially rescues RKO-induced neuroinflammation in females.•RKO induces hyperlocomotion, mania-like behaviors, and memory impairments.•Microglia depletion improves RKO-induced mood dysregulation.

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关键词

Circadian,Neuroinflammation,Microglia,Rev-Erbα,Mood,Cognition

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