Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study.

Paweł Widera,Paco M J Welsing,Samuel O Danso, Sjaak Peelen,Margreet Kloppenburg,Marieke Loef, Anne C Marijnissen,Eefje M van Helvoort,Francisco J Blanco,Joana Magalhães,Francis Berenbaum,Ida K Haugen,Anne-Christine Bay-Jensen,Ali Mobasheri,Christoph Ladel,John Loughlin,Floris P J G Lafeber,Agnès Lalande,Jonathan Larkin,Harrie Weinans,Jaume Bacardit

Osteoarthritis and cartilage open（2023）

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摘要

The machine learning-supported recruitment resulted in enriched selection of progressive patients. Further research is needed to improve structural progression prediction and assess this strategy in an interventional trial.

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关键词

osteoarthritis clinical trials,patient selection,clinical trials,learning-supported,imi-approach

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