Temporal relationships between Staphylococcus aureus colonization, filaggrin expression, and pediatric atopic dermatitis.

Arya Dahal,Wan Chi Chang,Cassandra Almasri,Elisabet Johansson,Makenna Hurd,Veronica Velasquez,Brittany Grashel,Daniel Spagna,Seth Jenkins,David Morgan,Latha Satish,Lisa J Martin,Jocelyn M Biagini, Gurjit K Khurana Hershey

Allergy（2023）

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摘要

Our findings are the first to present longitudinal quantitative FLG expression and S. aureus skin colonization in early life and suggest that a decrease in NL-FLG drives later colonization. Hence, therapies to maintain NL-FLG expression may prevent S. aureus colonization. Further, a longitudinal AD endotype of persistent colonization is characterized by increased AD severity, sensitization, and decreasing NL-FLG.

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