Impact of programmed death-ligand 1 (PD-L1) positivity on clinical and molecular features of patients with metastatic gastric cancer.

Minkyue Shin,Soomin Ahn,Jaeyun Jung,Sujin Hyung,Kyoung-Mee Kim,Seung Tae Kim,Won Ki Kang,Jeeyun Lee

Cancer medicine（2023）

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摘要

PD-L1 expression is an independent and sensitive biomarker for ICI therapy. Considering its significant association with several gene alterations, including PIK3CA mutations and MET amplification, combining ICI therapy with other targeted agents may be a promising therapeutic strategy for GC.

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关键词

combined positive score, Epstein-Barr virus, gastric cancer, immune checkpoint inhibition, microsatellite instability, next-generation sequencing, programmed death-ligand 1, tumor mutational burden

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