SIRT2 inhibitor SirReal2 enhances anti-tumor effects of PI3K/mTOR inhibitor VS-5584 on acute myeloid leukemia cells.

Yiming Luo,Haijun Zhao,Jingtao Zhu,Liyi Zhang,Jie Zha,Li Zhang, Yi Ding, Xinyi Jian,Junjie Xia,Bing Xu,Zhongquan Qi

Cancer medicine（2023）

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摘要

Taken together, the PI3K/mTOR inhibitor VS-5584 was effective in suppressing AML cell proliferation. PI3K/mTOR inhibitor combined with SIRT2 inhibitor exhibited a synergistic inhibitory effect on AML cells. Our findings offer promising therapeutic strategies and drug candidates for the treatment of AML.

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关键词

acute myeloid leukemia, anti-tumor effect, PI3K/mTOR, SIRT2

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