Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor

Yudai Imai,Ryo Suzuki,Daisuke Wakasugi,Daisuke Matsuda,Nozomi Tanaka-Yamamoto, Yuta Ohki,Masashi Mima,Mayumi Endo, Ryotaro Tabata, Hitomi Matsuzawa,Yoshitaka Hasegawa,Sota Kato,Mami Sugisaki,Hiroh Miyagawa,Natsuko Fujimoto,Takuya Fukunaga,Sayaka Kato,Teisuke Takahashi,Hiroyuki Kakinuma

Bioorganic & medicinal chemistry（2023）

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摘要

•Compound 2 was optimized using X-ray analysis and FMO calculation, resulting in 4e with increased potency against HPSE1.•Methylation of 6-hydroxyl group of 4e resulted in 18 with improved selecivity towards HPSE1 over GUSβ/GBA.•Compound 18 significantly suppressed serum HPSE1 activities in mice at 3, 30, and 100 mg/kg.

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关键词

Heparanase-1 inhibitor,Tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid,X-ray co-crystal structure,Fragment molecular orbital calculation

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