Iron‐Catalyzed Oxidative C−C Bond Cleavage of Unstrained Tertiary Alkyl Aromatics to Arylketones

Ning Xu, Lulu Zhou,Linlin Zhao,Mengying Guo,Linlin Yang,Wei Han

ADVANCED SYNTHESIS & CATALYSIS（2023）

Cited 0|Views6

No score

Abstract

We present here an iron-catalyzed oxidative C-sp3-C-sp3 bond cleavage of unstrained tertiary alkyl aromatics to provide a range of synthetically useful arylketones even with H2O2 as the oxidant. This method is operationally simple, scalable, and eco-friendly, as well as suitable for the late-stage oxidation of complex molecules bearing hydroxy groups, making it a valuable tool in organic synthesis.

Translated text

Key words

ketones,C-sp3-C-sp3 bond cleavage,hydrogen peroxide,iron,oxidation,synthetic methods

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined