Zn (II) octahedral complex with new ketimine ligand: design, synthesis and single-crystal studies

The present investigation deals with the synthesis and single-crystal X-ray analysis of Zu (II) coordination complex of ketimine ligand which was obtained by reaction of dehydroacetic acid with carbohydrazide ( 3 ) and characterized the title compound with elemental analysis, multinuclear ( 1 H and 13 C) NMR, UV visible, and FTIR spectral data. It crystallized in orthorhombic crystal system with space group Pbcn and unit cell dimensions: a = 18.7959 (4), b = 11.2890 (2) and c = 13.4480 (3) Å, and α = β = γ = 90°. The suggested geometry obtained after experimental analysis was distorted octahedral due to some angle strain between axial homonuclear N donor atoms around central Zn, and it was very close to the expected geometry. The DNA co-relation analysis was carried out by using fixed concentration of Calf Thymus DNA against the solution of analyte using UV spectroscopy. The ligand and metal complexes were examined for antibacterial and fungal activities against E. coli , M. luteus , E. aerogenes , S. aureus, and C. albicans, and the titled complex was found to be active against all the tested strains.