Parthenolide Attenuates Atherosclerosis Progression via Autophagy Induction through Caspase-1 Inhibition

Medium-and large-size arteries are affected by atherosclerosis, a chronic inflammatory and immune disorder that first thickens the artery wall because of the accumulation of inflammatory cells, and formation of fatty streaks that form fibrous capsules with macrophages at the area of damage. The pathophysiology of CVD is mostly influenced by atherosclerosis. Atherosclerosis is fundamentally influ-enced by autophagy, which opens up new avenues for its therapy. The present study evaluates the effect of Parthenolide in retarding progression of atherosclerosis. The results find that parthenolide signifi-cantly reduce oxidative stress (plasma f2-isopostane), tissue p62, caspase-1 mRNA expression and signifi-cant reduction in lesion severity degree (initial). These finding suggest that parthenolide retarding pro-gression of atherosclerosis.