Halogen bonded supramolecular assemblies constructed from azulene derivatives and perfluorinated di-/triiodobenzenes

Two series of binary halogen-bonded co-crystals involving perfluorinated di- and triiodobenzene (1,2-ditfb, 1,4-ditfb and 1,3,5-titfb) and 1,3-azulenedicarboxaldehyde (azdicho) 1 and 1,3-bis(4-pyridyl)azulene (azbbpy) 2 are reported. The crystal structures of the six new co-crystals show primarily OMIDLINE HORIZONTAL ELLIPSISI or NMIDLINE HORIZONTAL ELLIPSISI interactions, and the subsidiary weak C-HMIDLINE HORIZONTAL ELLIPSISF and p-p interactions of the aromatic units. Because the halogen-bond acceptors contain different heteroatoms and length size, the supramolecular recognition in the co-crystal is quite different. Besides novel structural features formed via halogen-bonding interactions, our results showed that the azulene moiety plays a unique organizing role in the formation and stabilization of supramolecular aggregates through p-p stacking interactions. These non-covalent interactions are investigated by theoretical studies through Hirshfeld surface analysis and DFT calculations followed by topological analysis of the electron density distribution within the QTAIM approach. The co-crystals were also investigated in solution by NMR spectroscopy through F-19-NMR and H-1,N-15-HMBC experiments.