Design and Investigation of the DM- PC-TFET-Based Biosensor for Breast Cancer Cell Detection

In this paper, a dielectric modulated polarity control tunnel field-effect transistor (DM-PC-TFET)- based biosensor has been proposed for the first time for breast cancer cells (BCCs) detection. The detection method is based on the significant difference in dielectric constant between cancerous and healthy breast cell lines in the microwave frequency band.When BCCs with different dielectric constants are filled in the sensing region of the proposed DM-PC-TFET-based biosensor, the electrical characteristics of the device vary, allowing for early-stage breast cancer detection. The sensing ability of the proposed biosensor has been investigated in terms of variation in drain current, threshold voltage, subthreshold swing, ON/OFF current ratio, and transconductance characteristics. The proposed bio-sensor demonstrates drain current sensitivity of 7.82× 10^10 , I _ON /I _OFF ratio sensitivity of 2.01× 10^9 , and trans-conductance sensitivity of 2.32× 10^12 for T47D (a breast cancer cell line). Additionally, the proposed biosensor’s selectivity, linearity, and noise characteristics are evaluated in this study too. Furthermore, the sensitivity of the DM-PC-TFET biosensor has also been investigated with variations in BCCs charge density, temperature, device geometry, and non-uniform arrangement of cancer cell lines within the nano-cavity region. The simulation results of the proposed biosensor are generated using a 2D technology computer-aided design tool. The results demonstrate that the proposed biosensor can be used as a suitable and efficient nano-device for the early detection of breast cancer.