KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors.

Alice Mac Donald, Delphine Guipouy,William Lemieux, Mario Harvey,Louis-Jean Bordeleau,David Guay, Hugo Roméro,Yuanyi Li, Renaud Dion,Kathie Béland,Elie Haddad

Frontiers in immunology（2023）

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摘要

Our results demonstrate that knockout is an effective strategy to improve NK cell antitumor activity against HLA-E tumors and could be applied in the development of NK cell therapy for solid tumors.

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关键词

nk cell antitumor activity,hla-e-mediated

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