AI-enabled Cardiac Chambers Volumetry In Non-contrast Cardiac CT Scans Detects HfREF Vs. HfPEF

Introduction: We have developed an AI-enabled automated volumetry of cardiac chambers (AutoChamber) that works both on non-contrast and contrast-enhanced cardiac CT scans used for coronary artery calcium (CAC) score and coronary CT angiography (CCTA), as well as lung cancer screening CT scans. We have previously reported the agreement between AutoChamber measurements in CAC vs. CCTA, CAC vs lung scans, and cardiac MRI measurements. Here we report echocardiography-based ejection fraction (EF) data showing the ability of AutoChamber in distinguishing heart failure with reduced ejection fraction (HFrEF) versus heart failure with preserved ejection fraction (HFpEF).