N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer’s Disease

•First report on the successful inhibition of butrylcholinesterases with novel 3-aminooxindole compounds; a best inhibition of 27 nM was obtained.•All compounds were selective for BuChE over AChE.•First report on the application of 3-propargylamineoxindoles against MAO A and B.•Insightful molecular docking studies for interactions of key inhibitors with hBuChE.•Insightful STD-NMR studies validating the mode of interaction for the most potent BuChE inhibitors.