Electrophysiological Characterisation of Calcium Channel Mutant, Cav1.2-R1586Q, Associated With Long QT Syndrome 8

Long QT syndrome 8 (LQT8) is a rare genetic disorder that affects several organs, including the heart. The most critical clinical manifestation of LQT8 is the prolonged time required for the heart to complete a cycle of its electrical activity, known as the “QT interval”. Prolonged QT interval increases the risk of developing life-threatening cardiac arrhythmias and cardiac arrest. Mutations in several ion channels are known to cause LQT8, including Cav1.2.