Dyslipidemia alters the binding specificity of secreted IGM antibodies in atherosclerotic mice

Background and Aims: It is well established that both hypercholesterolemia and immunity contribute to atherosclerosis. Importantly, IgM antibodies have been shown protective in murine atherosclerosis, and epidemiological studies in humans demonstrate a negative correlation between IgM levels and cardiovascular events. However, the impact of hyperlipidemia and atherogenesis on the IgM repertoire is unknown.