Physiologically based pharmacokinetic modelling to characterize enterohepatic recirculation and predict food effect on the pharmacokinetics of hyzetimibe.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences（2023）
摘要
The established PBPK model could describe the concentration-time profiles of hyzetimibe and M1 well with good prediction performance. A fully mechanistic model of enterohepatic recirculation warrants further investigation.
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关键词
pharmacokinetic modelling,pharmacokinetics,enterohepatic recirculation,food effect
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