Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis.

Nian Liu,Mingjie Yan,Qian Tao,Jie Wu,Jing Chen,Xiang Chen,Cong Peng

Journal for immunotherapy of cancer（2023）

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摘要

Taken together, our results demonstrated the role of TCA cycle in immune checkpoint blockade and provided a novel combination strategy for anti-PD-1 immunotherapy in melanoma treatment.

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melanoma cells

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