Decidualized human decidual stromal cells inhibit chemotaxis of activated T cells: a potential mechanism of maternal-fetal immune tolerance.

Tatiana Llorca,Maria Jose Ruiz-Magaña,Rocio Martinez-Aguilar,Olga María García-Valdeavero,Lucia Rodríguez-Doña,Ana Clara Abadia-Molina,Carmen Ruiz-Ruiz,Enrique G Olivares

Frontiers in immunology（2023）

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摘要

These results confirm in humans that decidualization of DSCs inhibits the expression by these cells of chemokines that attract Th1 and Tc cells and induces the secretion by DSCs of factors that inhibit the chemotaxis of these lymphocytes, thus preventing the arrival of abortigenic T cells in the decidua.

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关键词

chemotaxis, decidual stromal cells, decidualization, Th1 cells, Tc cells

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