Pre-XDR Congenital Tuberculosis in an Extremely Premature Baby

Alison Boast, Jeu Ann How, Charis Lau,Arun Sett, Damien Gilby,Andrew Burke, Brett McWhinney, Connor Wright, Adrian Tramontana,Maria Globan,Justin Denholm,Stephen M. Graham,Joshua Osowicki

CLINICAL INFECTIOUS DISEASES（2024）

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摘要

We describe a case of congenital tuberculosis in an extremely premature baby, with rapid molecular detection of a pre-extensively drug-resistant (XDR) pattern of drug resistance. The baby was treated successfully with a regimen including bedaquline and delamanid, drugs not previously described in the treatment of congenital tuberculosis (TB).

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关键词

congenital tuberculosis,multidrug resistant,premature,neonate,therapeutic drug monitoring

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