Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome.

Alexandra N Brown-Suedel,Lisa Bouchier-Hayes

The EMBO journal（2023）

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摘要

Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO-PIDDosome on extra centrioles. Activation of this protein complex leads to NF-κB activation that, in turn, induces NK cell-mediated cell clearance.

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natural killer cells,polyploid cells,pidd1,balanced genome

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