Type 2 innate lymphoid cells are protective against hepatic ischaemia/reperfusion injury

Qi Cao,Ruifeng Wang,Zhiguo Niu,Titi Chen,Farhana Azmi,Scott A. Read,Jianwei Chen,Vincent W.S. Lee,Chunze Zhou,Sohel Julovi,Qingsong Huang,Yuan Min Wang,Malcolm R. Starkey,Guoping Zheng,Stephen I. Alexander,Jacob George,Yiping Wang,David C.H. Harris

JHEP reports : innovation in hepatology（2023）

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摘要

•ILC2s played critical roles in IL-33-mediated hepatoprotection in IRI mice.•IL-13 induction of anti-inflammatory Mφ and IL-5 elevation of eosinophils mediate the protective effect of ILC2s in vivo.•Human ILC2s protected against hepatic IRI in NSG mice, supporting their therapeutic potential in humans.

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关键词

Innate lymphoid cells,Hepatic ischaemia/reperfusion injury,IL-33,Eosinophils,Macrophages

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