Hydrogel-based 3D human iPSC-derived neuronal culture for the study of rabies virus infection.

Papon Muangsanit,Thanathom Chailangkarn, Nathiphat Tanwattana,Ratjika Wongwanakul,Porntippa Lekcharoensuk,Challika Kaewborisuth

Frontiers in cellular and infection microbiology（2023）

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摘要

We demonstrated the use of a hydrogel-based 3D hiPSC-derived neuronal model, a highly promising technology, to study RABV infection in a more physiological environment, which will broaden our understanding of RABV-host interactions in the CNS.

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human-induced pluripotent stem cells, neurons, hydrogels, culture model, rabies virus, NanoString, gene expression, virus-host interaction

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