Outer mitochondrial membrane E3 Ub ligase MARCH5 controls mitochondrial steps in peroxisome biogenesis.

Nicolas Verhoeven,Yumiko Oshima,Etienne Cartier,Albert Neutzner,Liron Boyman,Mariusz Karbowski

bioRxiv : the preprint server for biology（2023）

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摘要

The authors found that mitochondrial E3 Ub ligase MARCH5 controls the formation of mitochondria-derived pre-peroxisomes. The data support the hybrid, mitochondria-dependent model of peroxisome biogenesis and reveal that MARCH5 is an essential mitochondrial protein in this process.

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