Extensions of the causal framework to Mendelian randomisation and gene-environment interaction
The Behavioral and brain sciences(2023)
摘要
In our commentary we ask whether we should ultimately endeavour to find the deep causes of behaviours? Then we discuss two extensions of the proposed framework: (1) Mendelian randomisation and (2) hypothesis-free gene-environment interaction (leveraging heterogeneity in genetic associations). These complementary methods help move us towards second-generation causal knowledge, ultimately understanding mechanistic pathways and identifying more effective intervention targets.
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关键词
mendelian randomisation,causal framework,gene–environment interaction
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