Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension.

A Dushani C U Ranasinghe, Maggie Holohan,Kalyn M Borger,Deborah L Donahue,Rafael D Kuc, Martin Gerig, Andrew Kim,Victoria A Ploplis,Francis J Castellino,Margaret A Schwarz

Circulation research（2023）

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摘要

SPHK2 expression and its activation of the reversible histone H3K9 acetylation in human pulmonary artery smooth muscle cell represent new therapeutic targets that could mitigate PH vascular remodeling.

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关键词

chromatin, endothelial cells, epigenomics, hypertension, pulmonary

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