Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis.

Wen-Jie Zhao, Xin Liu,Man Hu,Yu Zhang,Peng-Zhi Shi,Jun-Wu Wang,Xu-Hua Lu,Xiao-Fei Cheng,Yu-Ping Tao,Xin-Min Feng,Yong-Xiang Wang,Liang Zhang

World journal of stem cells（2023）

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摘要

In summary, the present study provides evidence that Que reduces oxidative stress-induced senescence of NPMSCs the miR-34a/SIRT1 signaling pathway, suggesting that Que may be a potential agent for the treatment of IDD.

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关键词

Quercetin, Nucleus pulposus-derived mesenchymal stem cells, Oxidative stress, Senescence, Intervertebral disc degeneration, miR-34a-5p/SIRT1 pathway

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