Abnormal genetic and epigenetic patterns of m6A regulators associated with tumor microenvironment in colorectal cancer.

Shuwei Ren,Yanhong Xiao,Huihui Wang,Lu Zhao,Hui Li,Lili Wei,Yongsheng Huang,Huanliang Liu

Translational cancer research（2023）

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摘要

Aberrant expression of m6A regulators is associated with mutation, CNV, and chromatin accessibility, owing to both genetic and epigenetic modifications. The TME infiltration characterization of m6A regulators could guide the development of more effective immunotherapy strategies in CRC.

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关键词

colorectal cancer,tumor microenvironment,epigenetic patterns

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