Divergent CD4 + T-cell profiles are associated with anti-HLA alloimmunization status in platelet-transfused AML patients.

Mehdi Khelfa,Mathieu Leclerc,Stéphane Kerbrat,Yakout Nait Sidenas Boudjemai, Médine Benchouaia,Déborah Neyrinck-Leglantier,Léonie Cagnet, Lylia Berradhia,Marie Tamagne,Laure Croisille,France Pirenne,Sébastien Maury,Benoît Vingert

Frontiers in immunology（2023）

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摘要

Our results thus reveal divergent CD4+ TL characteristics correlated with anti-HLA alloimmunization status in transfused AML patients. These differences, characterizing CD4+ TLs independently of any specific antigen, should be taken into account when considering the immune responses of patients to infections, vaccinations, or transplantations.

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acute myeloid leukemia, alloimmunization, multi-omics, CD4+T lymphocytes, platelet transfusion

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