Circulating extracellular vesicles in human cardiorenal syndrome promote renal injury in Kidney on Chip system.

Emeli Chatterjee,Rodosthenis S Rodosthenous,Ville J Kujala,Priyanka Gokulnath,Michail Spanos,H Immo Lehmann,Getulio P de Oliveira-Jr,Mingjian Shi,Tyne W Miller-Fleming,Guoping Li,Ionita Ghiran,Katia Karalis,JoAnn Lindenfeld,Jonathan D Mosley,Emily S Lau,Jennifer E Ho,Quanhu Sheng,Ravi Shah,Saumya Das

JCI insight（2023）

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摘要

Plasma EVs in CRS patients elicit adverse transcriptional and phenotypic responses in a KOC model by regulating biologically relevant pathways, suggesting a role for EVs in CRS.

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