Facile Construction of Antimicrobial Surface via One-Step Co-Deposition of Peptide Polymer and Dopamine

The infections associated with implantable medical devices can greatly affect the therapeutic effect and impose a heavy financial burden. Therefore, it is of great significance to develop antimicrobial biomaterials for the prevention and mitigation of healthcare-associated infections. Here, a facile construction of antimicrobial surface via one-step co-deposition of peptide polymer and dopamine is reported. The co-deposition of antimicrobial peptide polymer DLL60BLG40 with dopamine (DA) on the surface of thermoplastic polyurethane (TPU) provides peptide polymer-modified TPU surface (TPU-DLL60BLG40). The antimicrobial test shows that the TPU-DLL60BLG40 surfaces of the sheet and the catheter both exhibit potent killing of 99.9% of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). In addition, the TPU-DLL60BLG40 surface also exhibits excellent biocompatibility. This one-step antimicrobial modification method is fast and efficient, implies promising application in surface antimicrobial modification of implantable biomaterials and medical devices. This study reports a facile construction of antimicrobial surface via one-step co-deposition of host defense peptide-mimicking peptide polymer and dopamine, with the killing efficacy of 99.9% against both Gram-positive bacteria and Gram-negative bacteria and excellent biocompatibility. The method is fast and effective and is a promising method for antimicrobial surface modification of implantable biomaterials and medical devices.image