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Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade.

Cancer discovery(2023)SCI 1区

Dana Farber Canc Inst | Blavatnik Inst | Princeton Univ | Harvard Med Sch

Cited 5|Views36
Abstract
Abstract The tumor microenvironment (TME) restricts antitumor CD8+ T-cell function and immunotherapy responses. Cancer cells compromise the metabolic fitness of CD8+ T cells within the TME, but the mechanisms are largely unknown. Here we demonstrate that one-carbon (1C) metabolism is enhanced in T cells in an antigen-specific manner. Therapeutic supplementation of 1C metabolism using formate enhances CD8+ T-cell fitness and antitumor efficacy of PD-1 blockade in B16-OVA tumors. Formate supplementation drives transcriptional alterations in CD8+ T-cell metabolism and increases gene signatures for cellular proliferation and activation. Combined formate and anti–PD-1 therapy increases tumor-infiltrating CD8+ T cells, which are essential for enhanced tumor control. Our data demonstrate that formate provides metabolic support to CD8+ T cells reinvigorated by anti–PD-1 to overcome a metabolic vulnerability in 1C metabolism in the TME to further improve T-cell function. Significance: This study identifies that deficiencies in 1C metabolism limit the efficacy of PD-1 blockade in B16-OVA tumors. Supplementing 1C metabolism with formate during anti–PD-1 therapy enhances CD8+ T-cell fitness in the TME and CD8+ T-cell–mediated tumor clearance. These findings demonstrate that formate supplementation can enhance exhausted CD8+ T-cell function. See related commentary by Lin et al., p. 2507. This article is featured in Selected Articles from This Issue, p. 2489
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Tumor Microenvironment,Tumor Growth,Cancer Cell Metabolism,Metabolism
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要点】:本研究发现补充甲酸(formate)可以增强抗肿瘤CD8+ T细胞的代谢适应性和PD-1阻断疗法的疗效。

方法】:通过分析CD8+ T细胞在一碳代谢(1C代谢)中的变化,并采用甲酸进行代谢补充。

实验】:在B16-OVA肿瘤模型中,通过甲酸补充和PD-1阻断联合治疗,发现甲酸补充可驱动CD8+ T细胞转录变化,增强细胞增殖和激活基因表达,增加肿瘤浸润CD8+ T细胞数量,提高肿瘤控制效果。实验使用了B16-OVA肿瘤模型。