En route to local glioblastoma treatment with temozolomide doped hyaluronan fibres: formulation and in vitro cell studies.

Marie Belhajová,Aleš Vícha,Ladislav Burgert,Iveta Brožková,Ludmila Michalíčková,Radim Hrdina, Tomáš Moravec,David Netuka,Zdeněk Musil,Radim Hrdina

RSC medicinal chemistry（2023）

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摘要

We report the preparation, characterisation and tests of hyaluronan fibres containing up to 50 w/w% of temozolomide for local glyoblastoma treatment. These fibres form a hydrogel upon contact with cerebrospinal fluid on the treatment spot.

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hyaluronan fibres,local glioblastoma treatment,temozolomide

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