Calcium handling dysfunction and cardiac damage following acute ventricular preload challenge in the dystrophin-deficient mouse heart.

Vivian Haffner,Zahra Nourian,Erika M Boerman,Michelle D Lambert,Laurin M Hanft,Maike Krenz,Christopher P Baines,Dongsheng Duan,Kerry S McDonald,Timothy L Domeier

American journal of physiology. Heart and circulatory physiology（2023）

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摘要

In conclusion, these data indicate susceptibility to preload-induced Ca overload, ventricular damage, and ventricular dysfunction in male Dmd hearts. Our data support the hypothesis that cardiomyocyte Ca overload underlies cardiac dysfunction in muscular dystrophy.

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关键词

calcium,acute ventricular preload challenge,cardiac damage,dystrophin-deficient

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